In 2025, blockchain is no longer a “nice-to-have experiment.” It’s a critical layer of enterprise infrastructure, just like cloud or databases. CIOs and CTOs aren’t asking “should we use most popular blockchains?” anymore—they’re asking “which the most popular blockchains makes sense for our business case?”
At NOWNodes, we support over 110+ blockchains and process hundreds of millions of RPC requests every month. That gives us a rare vantage point: not just what the market says, but what enterprises actually use when their systems go live.
Here’s our take on the most popular blockchains dominating enterprise adoption in 2025—based on both market data and our own internal analytics.
Ethereum: The Institutional Anchor
Ethereum remains the default enterprise blockchain. Its developer ecosystem, compliance-friendly tooling, and vast liquidity pools make it hard to replace. Enterprises choose Ethereum when they want long-term stability and the assurance of a massive ecosystem.
Market metrics (2025):
- TVL: ~$78,000,000,000+ locked in DeFi.
- Daily active addresses: ~600k.
NOWNodes data:
- Ethereum accounts for 28% of all enterprise RPC requests we handle.
- We’ve seen a 19% YoY growth in Ethereum RPC traffic from enterprise clients, largely driven by tokenization pilots and DeFi integrations.
BNB Chain: The Enterprise Workhorse
BNB Chain offers a mix of low fees, high throughput, and wide retail adoption. Enterprises targeting consumer-scale adoption—think neobanks, wallets, loyalty apps—choose BNB Chain when costs and scalability trump prestige.
Market metrics (2025):
- Daily transactions: ~11.5M.
- Active addresses: ~4.4M/day.
NOWNodes data:
- BNB Chain makes up 22% of enterprise RPC requests on our platform.
- In fintech and payment clients, BNB Chain endpoints see 30% more average traffic compared to Ethereum.
BNB Chain may not get the same press as Ethereum or Solana, but it’s often the most practical choice for enterprises with millions of daily users.
Solana: The Performance Leader
Solana is where enterprises go when speed is mission-critical. Gaming companies, high-frequency financial apps, and social platforms all rely on Solana’s sub-second latency and high TPS capacity.
Market metrics (2025):
- Daily transactions: ~80M+.
- Active wallets: ~3.5M/day.
- Solana ecosystem: 2,000+ active projects.
NOWNodes data:
- Solana RPC traffic grew 61% YoY—the fastest growth of any chain we support.
- Enterprises in gaming and consumer apps now account for 40% of our Solana request volume.
Solana isn’t just fast—it’s consistently proving it can handle enterprise-scale workloads. For use cases where UX is non-negotiable, Solana is winning mindshare.
Bitcoin: The Bedrock of Trust
Bitcoin may not power dApps, but it powers trust. Enterprises integrate Bitcoin for treasury, settlement, and wrapped assets. Its role is less about programmability and more about being the most secure and recognized blockchain globally.
Market metrics (2025):
- Market cap: ~$2,000,000,000,000
- Daily transactions: ~500000.
NOWNodes data:
- Bitcoin RPC requests account for 15% of our enterprise traffic.
- Most enterprise queries are related to payments, custody, and compliance reporting.
No enterprise blockchain strategy is complete without Bitcoin. It’s the “trust layer” others build on top of.
Polygon: Ethereum’s Scalable Twin
Polygon has positioned itself as Ethereum’s enterprise scaling solution. With zkEVM and supernets, it offers both compatibility and flexibility. Enterprises pick Polygon when they want Ethereum-level credibility at a fraction of the cost.
Market metrics (2025):
- TVL: ~$5,241,208,614.
- Daily active addresses: ~551k.
- 500+ enterprise and institutional partnerships.
NOWNodes data:
- Polygon now drives 18% of enterprise RPC requests on our platform.
- We’ve seen a 47% YoY increase in Polygon usage, especially from gaming, retail, and enterprise tokenization clients.
Polygon isn’t just an “Ethereum sidekick” anymore—it’s a serious enterprise platform in its own right.
What the Data Really Shows
Looking across all networks, the patterns are clear:
- Ethereum still leads, but its share is being redistributed to cost-efficient chains.
- Solana and Polygon are the fastest climbers, capturing enterprise projects that demand UX and scalability.
- BNB Chain quietly dominates high-volume consumer apps, despite flying under the radar.
- Bitcoin remains the foundation, not for apps, but for brand-level trust and settlement.
The Enterprise Blockchain Stack of the Future
From where we sit, powering millions of daily RPC calls, the enterprise blockchain stack in 2025 looks like this:
- Ethereum + Polygon → core smart contract infrastructure.
- Solana → user-facing, high-performance apps.
- BNB Chain → cost-efficient fintech and payments backbone.
- Bitcoin → treasury and settlement layer.
Final Words
The question for enterprises isn’t “which blockchain will win?”—it’s which combination fits your use case best. And in 2025, the winning chains are those delivering trust, speed, and scale—qualities we see firsthand every day in our RPC request data.
At NOWNodes, we’re proud to power this growth and give enterprises the infrastructure to scale Web3 into production.
